Emprila 2.5%+2.5% Cream, 30g

✔️ Description:

Emprila 5 g Cream is a topical preparation containing two local anesthetics that temporarily numb the skin. It is applied to intact, unbroken skin to reduce pain before minor medical procedures such as needle insertion, wound suturing, or minor dermatological interventions. The cream works by temporarily blocking nerve signals in the applied area, resulting in reduced pain sensation.

✔️ Dosage

Adult Dosage

Minor Dermatological Procedures (e.g., IV cannulation, venipuncture)

Apply 2.5 g over 20–25 cm² of intact skin

Leave in place for at least 1 hour

Painful Dermatological Procedures (large areas)

Apply 2 g per 10 cm²

Leave on for at least 2 hours

Maximum analgesia occurs within 2–3 hours and may last 1–2 hours after removal

Genital Use

Male genital skin: Apply 1 g per 10 cm² for 15 minutes under occlusion

Female external genital skin: Apply 5–10 g for 5–10 minutes (occlusive dressing optional)

Pediatric Dosage

Neonates (<37 weeks gestation): Use not recommended

0–3 months (<5 kg): Maximum 1 g; area ≤10 cm²; ≤1 hour

3–12 months (>5 kg): Maximum 2 g; area ≤20 cm²; ≤4 hours

1–6 years (>10 kg): Maximum 10 g; area ≤100 cm²; ≤4 hours

7–12 years (>20 kg): Maximum 20 g; area ≤200 cm²; ≤4 hours

✔️ Side Effects:

Side Effects

Very Common (>10%)

Skin blanching or pallor

Application site redness, pain, or burning sensation

Common (1–10%)

Altered temperature sensation

Application site swelling

Itching

Rare (<1%)

Rash

Methemoglobinemia

Seizures

Cardiac effects

Allergic reactions (urticaria, angioedema, bronchospasm, anaphylaxis)

✔️ Interaction

Increased risk of toxicity when used with medications that induce methaemoglobinemia

Additive cardiac effects may occur when used with Class I or Class III antiarrhythmics

✔️ Contraindications (ব্যবহার নিষেধ):

• Preterm neonates (<37 weeks of gestation)
• Infants under 12 months receiving methaemoglobin-inducing drugs
• Patients with congenital or idiopathic methaemoglobinemia
• Application on broken, inflamed, or infected skin
• Use on mucous membranes unless specifically directed

✔️ Precautions & Warnings

• Use with caution when applying to large skin areas or leaving on for more than 2 hours
• Caution in patients with severe hepatic impairment
• Use carefully in patients taking Class I or Class III antiarrhythmic drugs
• Dose adjustment may be required in elderly, debilitated, or acutely ill patients
• Avoid use near the eyes or on open wounds
• Use during pregnancy and breastfeeding only if clearly necessary

✔️ Storage:

• Store in a cool and dry place away from sunlight.